When Sam teams up with a familiar face, Dean is forced to team up with a laid-back hunter, Garth, and ends up working at cross purposes to his brother.
Bored with the direction in which his life is heading and still banned from athletics, Curtis decides to use his new gender-swap power so that he can compete again.
An angry ghost goes after mediums in Lily Dale, the most psychic town in America, and the brothers have to figure out who the next victim will be from a population filled with nothing but psychics.